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Prof. Zhiqiang Su’s team published a review article in ‘Chem. Soc. Rev.’

Prof. Zhiqiang Su’s team published a review article in ‘Chem. Soc. Rev.’

      Recently, Prof. Zhiqiang Su’s team published a review article titled ‘The design and biomedical applications of self-assembled two-dimensional organic biomaterials’ in the international famous journal ‘Chem. Soc. Rev.IF=40.443’. In this review, they summarized recent advances in the fabrication, self-assembly principles, structural tailoring, functional control, and biomedical applications of 2DOBMs.

In recent years, lots of studies have demonstrated that various biomolecules, including DNA, proteins, peptides/peptoids, polymers, and other macromolecules, could be used to assemble into different 2DOBMs, such as grids, arrays, nanosheets, nanobelts, films, and membranes. It is well-known that self-assembly is a simple and highly efficient strategy to obtain 2DOBMs by both covalent and noncovalent interactions, such as hydrogen bonding, electrostatic interactions, hydrophobic interactions, π–π interactions, and van der Waals interactions. Generally, the self-assembly of biomaterials is controlled by several reaction conditions, such as the self-assembly time, temperature, solution concentration, pH, metal ions, and so on. 

Prof. Zhiqiang Su’s team concluded that various 2DOBMs based on the self-assembly of biomolecules like DNA, RNA, proteins, peptides, peptoids, viruses, and biopolymers could be designed and prepared by rationally adjusting both biomolecules–biomolecule and biomolecule–material interactions. Also, it is possible to tailor the functions of 2DOBMs by introducing other nanoscale/microscale building blocks such as NPs, carbon materials, different biomolecules, organic molecules, and inorganic scaffolds into the self-assembling biomolecular systems. Biomedical studies with the self-assembled 2DOBMs indicated that both structural and functional manipulations of 2DOBMs make them versatile candidates for creating next-generation functional biomaterials for biomedical and tissue engineering applications, which are significantly boosting the scientific research and healthcare marketing of biomaterials. 2DOBMs have unique structures and functions, and they exhibited significant advantages for various demands compared to other traditional 2D materials; however, looking to the future, there are still some aspects in this research field that should attract further attention.

Dr.Xiaoyuan Zhang is the first author of the paper. Prof. Zhiqiang Su is the corresponding author. Beijing University of Chemical Technology is the first affiliated institute. The work was financially supported by the National Natural Science Foundation of China.

Review Information: Xiaoyuan Zhang, Coucong Gong, Ozioma Udochukwu Akakuru, Zhiqiang Su*, Aiguo Wu*, and Gang Wei*, The design and biomedical applications of self-assembled two-dimensional organic biomaterials. Chemical Society Reviews 2019, 48, 5564-5595

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